Synthesis of Trifluoromethyl Tetrafluoro‐λ 6 ‐sulfanyl‐Substituted Alkenes, Ketones, and Acids: Polar Hydrophobic Building Blocks
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چکیده
منابع مشابه
Enantioselective rhodium-catalyzed addition of arylboronic acids to trifluoromethyl ketones.
The catalytic asymmetric 1,2-addition of a series of arylboronic acids to 2,2,2-trifluoroacetophenones is described with high isolated yields (up to 96%) and good enantioselectivities (up to 83% ee) using a rhodium(I)/phosphoramidite catalyst.
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A two amino acid (hydrophobic and polar) scheme is used to perform the design on target conformations corresponding to the native states of 20 single chain proteins. Strikingly, the percentage of successful identification of the nature of the residues benchmarked against naturally occurring proteins and their homologues is around 75%, independent of the complexity of the design procedure. Typic...
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Cristian Micheletti, Flavio Seno, Amos Maritan and Jayanth R. Banavar (1)INFM-Dipartimento di Fisica, Università di Padova, Via Marzolo 8, 35131 Padova, Italy (2) International School for Advanced Studies (S.I.S.S.A.), Via Beirut 2-4, 34014 Trieste, Italy (3) Department of Physics and Center for Materials Physics, 104 Davey Laboratory, The Pennsylvania State University, University Park, Pennsyl...
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ژورنال
عنوان ژورنال: European Journal of Organic Chemistry
سال: 2018
ISSN: 1434-193X,1099-0690
DOI: 10.1002/ejoc.201701568